More than 2,000 homes in parts of Manchester are being evacuated due to flooding caused by Storm Christoph.
The Environment Agency (EA) has issued two severe flood warnings, which means danger to life, for the Didsbury and Northenden areas.
Assistant Chief Constable Nick Bailey of Greater Manchester Police has warned some of those affected would "be Covid-positive or isolating at home".
Earlier, Boris Johnson urged people to follow evacuation advice.
He said the government was working to ensure it was "totally prepared" for floods "in every part of the UK".
A major incident was earlier declared for the Greater Manchester area where up to 3,000 properties were feared to be at risk.
Mr Johnson urged people not to stay in their homes if they were told to evacuate.
"If you are told to leave your home then you should do so.
"People may think this is a minor issue at the moment, still relevantly minor by standards of previous floods, but never underestimate the suffering, the misery, that floods can cause people."
Under government restrictions due to the current national lockdown people are allowed to leave their homes to escape harm.